![]() ![]() By using the normal curve as a reference system, a quantitative evaluation of the blood volume disturbance was proposed. In comparison with the normal curve, the hypertensive curve has two characteristics: 1) the curve was reset on the right-hand side and, 2) the slope was significantly shallower, indicating a reduced ability to decrease the volume per unit rise in resistance. ![]() A significant negative volume-resistance relationship was observed both in normal subjects (P < 0.005) and hypertensive patients (P < 0.001). Endogenous creatinine clearance was within normal ranges and sodium intake was 110 mEq/day. Cardiac and renal hemodynamics and total blood volume were determined in 28 normal subjects and 60 patients with untreated essential well-established hypertension. Altered blood volume regulation in sustained essential hypertension: A hemodynamic study. ![]()
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